S1 File -

Noncontact injuries are prevalent among professional football players. Yet, most research on this topic is retrospective, focusing solely on statistical correlations between Global Positioning System (GPS) metrics and injury occurrence, overlooking the multifactorial nature of injuries. This study introduces an automated injury identification and prediction approach using machine learning, leveraging GPS data and player-specific parameters. A sample of 34 male professional players from a Portuguese first-division team was analyzed, combining GPS data from Catapult receivers with descriptive variables for machine learning models—Support Vector Machines (SVMs), Feedforward Neural Networks (FNNs), and Adaptive Boosting (AdaBoost)—to predict injuries. These models, particularly the SVMs with cost-sensitive learning, showed high accuracy in detecting injury events, achieving a sensitivity of 71.43%, specificity of 74.19%, and overall accuracy of 74.22%. Key predictive factors included the player’s position, session type, player load, velocity and acceleration. The developed models are notable for their balanced sensitivity and specificity, efficiency without extensive manual data collection, and capability to predict injuries for short time frames. These advancements will aid coaching staff in identifying high-risk players, optimizing team performance, and reducing rehabilitation costs.