GO-enrichment analysis for comparison T1–C1, showing the most specific over- and under-represented biological process GO-terms for both up- and down-regulation.

NS: number of differentially expressed genes, annotated with a particular GO-term. FE: fold enrichment (>1: over-represented GO terms; <1: under-represented GO terms; 0: zero genes in the test group, annotated with a particular GO term; ∞: zero genes in the reference group, annotated with a particular GO term). FE for a particular GO term is calculated as follows: (number of genes with GO term in test group/number of genes with GO term in reference group)/(number of genes without GO term in test group/number of genes without GO term in reference group). P-value: significance measure (cut-off: 0.05) as calculated by Blast2GO during enrichment analysis.