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Gene expression profiling of FACS-purified striatal medium spiny neurons and striatum in Huntington's disease model mouse

NIAID Data Ecosystem2026-03-11 收录

神经退行性机制

细胞类型特异性转录组

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE113930 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2020-08-10

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To determine transcriptome changes in spinal cord induced by the GarsdelETAQ mutation. How mutations in broadly expressed housekeeping genes lead to neurodegeneration in specific cell types remains un

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The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases V

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Microglia play a pivotal role in the maintenance of brain homeostasis, but lose their homeostatic function during the course of neurodegenerative disorders. We identified a specific APOE-dependent mol

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Type I Interferon Signaling Mediates Microglial Dysfunction and Senescence in Human-Mouse Chimeric Brain Models of Down Syndrome and Alzheimer's Disease [single-cell RNA-seq]

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Microglia are critical for brain development and play a central role in Alzheimer's disease (AD) etiology. Down syndrome (DS), also known as trisomy 21, is the most common genetic origin of intellectu

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APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition [bulk RNA-seq]

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The Christchurch mutation (R136S) on the APOE3 (E3S/S) gene is associated with attenuation of tau load and cognitive decline despite the presence of a causal PSEN1 mutation and high levels of amyloid

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Gene expression profiling of FACS-purified striatal medium spiny neurons and striatum in Huntington's disease model mouse

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