Loss of H3.1K27me1 in Arabidopsis confers resistance to Geminivirus by sequestering DNA repair proteins onto host genome [RNA-seq]

Transcriptome-wide association studies (TWAS) to pinpoint enhanced expression of genes involved in DNA repair attributed to viral resistance of atxr5 atxr6. To investigate how the transcriptome is reprogramed upon virus infection, we performed comprehensive TWAS with high quality reads from mock-treated and virus-treated samples. Among genes showed enhanced expression upon virus inoculation, we observed that 365 genes that were expressed at higher levels in atxr5 atxr6 compared to Col-0, brca1 atxr5 atxr6, mbd9 atxr5 atxr6 and sac3b atxr5 atxr6, in both mock-treated and virus-inoculated samples. GO analysis classified the top three enriched biological processes into response to DNA damage, DNA repair, and DNA recombination.