Nucleotide mutation patterns and proportions in IgG VH3 mRNA sequences.

“% C nucleotides mutated” indicates the proportion of nucleotides in either the CDR1/2 or FR1/2/3 regions that were mutated relative to the total number of C nucleotides present in the unmutated reference sequence, expressed as a percent. “% of mutations that were C nts” indicates the proportion of mutations in either the CDR1/2 or FR1/2/3 regions that were C nucleotides in the unmutated reference sequence relative to the total number of mutations in the region expressed as a percent. The group medians are listed (individual patient mean ranges in parentheses). Overall p values are listed on the table.a Secondary analyses: all comparisons p>0.05.b Secondary analyses: control vs. viremic p0.05.