Gene expression in DCIS.COM with BCL9 knockdown

There is limited research on which specific Wnt targets are regulated by B-Cell Lymphoma-9 (BCL9) and whether BCL9 regulates other signaling pathways to drive cancer malignancy. Here we demonstrated that BCL9 drives DCIS invasive progression by regulation of genes involved in cellular growth, invasion and migration. RNA-seq was performed on the DCIS cell line (DCIS.COM) control and BCL9-knockdown (BCL9 KD) to elucidate gene expression changes with BCL9 knockdown