Proteomic profiling of extracellular vesicles from Nodal KO and control mouse placentas

This study evaluates the potential of placental extracellular vesicles (EVs) as biomarkers of midgestational pregnancy complications using a mouse model. EVs were isolated from embryonic day 10.5 (E10.5) placentas of control and uterine-specific Nodal knockout mice. Proteomic analyses revealed dysregulated molecules related to placental development, angiogenesis, and immune modulation. Several identified EV cargo components have known associations with complications such as IUGR and preeclampsia. These results suggest that placental EVs can reflect impaired placentation and may support early, non-invasive diagnostic strategies for reproductive disorders.