Concentration of B cells in blood of TRAF2DN/Bcl2 mice treated with empty liposomes or with triterpenoids.

TRAF2DN/Bcl-2 mice were injected i.v. with empty liposomes or with liposomes containing either CDDO or CDDO-Im at doses of 5, 10 or 20 mg/kg/day (corresponding to 17.3, 34.5 and 69 mg/m2/day, respectively). Each mouse received a total of nine injections administered over a period of 21–25 days. The concentration of B cells (×106/ml) in blood was monitored one day before the inoculation with drug (pre-treatment), after the inoculation of the 1st, 2nd, 3rd and 6th drug dosages, and 3 to 10 days after the final inoculation(post-treatment). (nd: not determined).