Data and code from: Accelerated intrinsic beating rate in heterogeneously coupled human pluripotent stem cell-derived cardiomyocytes can underlie focal ventricular tachycardia in regenerative therapy

This dataset contains data required to reproduce computational simulations presented in the 2026 paper by Gibbs & Boyle. This data set comprises (1) Geometric descriptions of the simulation domain (whole heart, tissue wedge, etc.), with point clouds interconnected by finite elements, each of which is associated with a vector encoding local myofiber orientation. (2) Parameter files describing functional cell- and tissue-scale properties of different tissue regions, perturbations to be applied to the model during the simulation (e.g., electrical stimuli), and numerical solver settings. (3) Initial condition state files describing the functional state of the model at the beginning of the simulation, if these conditions differ from the cell-scale default parameters. All of the above are stored in plain text or binary formats compatible with the openCARP framework, which is freely available for non-commercial use.
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## INFORMATION ABOUT THE RELATED PUBLICATION

Gibbs et al. (2026) Accelerated intrinsic beating rate in heterogeneously coupled human pluripotent stem cell-derived cardiomyocytes can underlie focal ventricular tachycardia in regenerative therapy

Link to published article: [https://doi.org/10.1016/j.premed.2026.100035](https://doi.org/10.1016/j.premed.2026.100035)

Please contact Dr. Patrick M. Boyle ([[e-mail]](mailto:[e-mail])) with any questions, concerns, complaints, or difficulties.

This dataset contains data required to reproduce computational simulations presented in the 2026 paper by Gibbs et al. (JPMHD 10.1016/j.premed.2026.100035). Please consider citing the original paper as well as this repository if you reuse, adapt, or extend any of the models or simulation protocols described below.

## Abstract from paper:

Cardiac stem cell therapies seek to replace damaged tissue following myocardial infarction to prevent heart failure. Human pluripotent stem-..., ,