Molecular Conservation of Zebrafish and Human Liver Tumors.. Danio rerio

Zebrafish has been advocated as a cancer model, but little is known about the molecular similarities between zebrafish and human tumors. Comparative analysis of microarray data from zebrafish liver tumors with those from four human tumor types revealed molecular conservation at various levels between fish and human tumors. This approach provides a useful strategy for identifying expression signature that is strongly associated with a disease phenotype. Keywords: Diseased vs normal. Overall design: We analyzed 10 arrays for zebrafish liver tumor tissue and 10 arrays for normal liver tissue.