Microvascular and Macrovascuar Complications of Type 2 Diabetes Mellitus: Exome Wide Association Analyses

With an escalating global burden, T2DM is associated to long-term complications that have contributed to the burden of morbidity and mortality worldwide. The objective of this manuscript is to conduct an Exome-Wide Association Study (EWAS) on T2DM Emirati individuals to improve our understanding on diabetes-related complications for a more enhanced disease management and improve therapeutic targets. To investigate the genetic loci associated with each diabetes-related complication category ( retinopathy, neuropathy, nephropathy, and heart disease) in the Emirati population. We genotyped 384 type 2 daiabtes patients, which was conducted on the Infinium Exome BeadChip (Illumina).