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Top1 and Top2-mediated replication fork integrity
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创建时间：
2010-06-05
相关数据集
Dynamics of de novo heterochromatin assembly and disassembly at replication forks ensures fork stability
Analysis of histone PTM levels in proliferating, quiescent and HU-treated TIG3 fibroblasts. TIG3 fibroblasts were cultured in the absence or presence of HU (600 μM) for at least 6 days, rendering cell
NIAID Data Ecosystem50
Structure and repair of replication-coupled DNA breaks
Using CRISPR/Cas9 nicking enzymes, we examine the interaction between the replication machinery and single strand breaks, one of the most common forms of endogenous DNA damage. We show that replicatio
NIAID Data Ecosystem30
Actin nucleators safeguard replication forks by limiting nascent strand degradation
Raw imaging files (representative) and source data for the manuscript ' Actin nucleators safeguard replication forks by limiting nascent strand degradation' Jadwiga Nieminuszczy, Pete
Figshare2023-05-10 更新20
Identification of RNAs containing TOP3B cleavage complexes. Identification of RNAs containing TOP3B cleavage complexes
Human TOP3B is unique as it can act as RNA topoisomerase. For identification of RNAs with TOP3B cleavage sites, we engineered a “self-trapping” mutant of TOP3B (R338W TOP3B) and performed performed na
NIAID Data Ecosystem50
Dynamic Control of RNA-DNA Hybrid Formation Orchestrates DNA2 Activation at Stalled Forks by RNAPII and DDX39A [ChIP-seq]
The accurate processing of stalled forks by the DNA2 nuclease is pivotal for replication fork restart, as excessive degradation poses a threat to genomic stability. However, the regulation of DNA2 act
NIAID Data Ecosystem20
