Dataset from Evaluation of HIV-Specific CD8+ T-Cell Responses and Escape Mutations as Explanations for the Observed Differences in Disease Progression Conferred by HLA Class I Alleles

ATN 026 investigated the association between HLA class I genotypes and differing HIV-1 disease progression. The study assessed HIV-1 specific CD8+ T-cell responses and the dominant HIV-1 genotype among individuals identified as HLA-B*27, B*35, B*53, and B*57 positive. Participants were followed for two years with medical history, physical exam, and blood sample collection performed every six months. All participants were previously enrolled in REACH, a 5-year longitudinal adolescent study. Some biospecimens are available; for inquiries, please contact Dr. Paul Goepfert ([e-mail]).