Table_1_Association Between ABCA1 Gene Polymorphisms and the Risk of Hypertension in the Chinese Han Population.docx

BackgroundHypertension is rising as a major public health burden around the world. This study explored the association between single-nucleotide polymorphisms (SNPs) in the adenosine triphosphate (ATP)-Binding Cassette Subfamily A1 (ABCA1) gene and hypertension among Chinese Han adults.MethodA total of 2,296 Han Chinese in southeast China were recruited for this study. We collected medical reports, lifestyle details, and blood samples from individuals. The polymerase chain reaction-ligase detection reaction (PCR-LDR) method was used to detect the genotypes of these SNPs in the ABCA1 gene.ResultsAfter adjusting some covariates, the additive and recessive models of the rs2472510 and rs2515614 were significantly associated with hypertension. The haplotypes TCTA (rs2297406-rs2472433-rs2472510-rs2515614) were associated with high SBP, and the haplotypes CCTA, TCTA, and TTTA were associated with high diastolic blood pressure (DBP).ConclusionThe results of the relationship between the polymorphisms of rs2297406, rs2472433, rs2472510, and rs2515614 in ABCA1 and hypertension in southeastern China would provide a theoretical basis for genetic screening and disease prevention.

全球范围内，背景性高血压正成为一项重大的公共卫生负担。本研究旨在探讨腺苷三磷酸（ATP）结合盒家族A1（ABCA1）基因中的单核苷酸多态性（SNPs）与中国汉族成年人高血压之间的关联。研究方法：本研究共招募了2,296名中国东南部的汉族成年人。我们收集了个体的医疗报告、生活方式细节和血液样本。采用聚合酶链反应-连接酶检测反应（PCR-LDR）方法检测ABCA1基因中这些SNPs的基因型。研究结果：在调整了一些协变量后，rs2472510和rs2515614的加性模型和隐性模型与高血压显著相关。TCTA（rs2297406-rs2472433-rs2472510-rs2515614）单倍型与高收缩压（SBP）相关，而CCTA、TCTA和TTTA单倍型与高舒张压（DBP）相关。研究结论：ABCA1基因中rs2297406、rs2472433、rs2472510和rs2515614多态性与中国东南部高血压之间的关系结果，将为遗传筛查和疾病预防提供理论依据。