Modulation of Pseudomonas aeruginosa quorum sensing by glutathione. Pseudomonas aeruginosa PAO1

We isolated a P. aeruginosa variant, which showed increased production of QS-regulated factors after repeated transfer in casein broth. This variant, P. aeruginosa QS*, had a mutation in the glutathione synthesis gene gshA. We describe several experiments that show gshA mutations affect the quorum sensing response.