Alisol B 23-acetate Ameliorates Azoxymethane/Dextran Sodium Sulfate-induced Murine Colitis-associated Colorectal Cancer via Modulating the Composition of Gut Microbiota and Improving Intestinal Barrier

In this study, we investigated the therapeutic potential of AB23A in mouse models of azoxymethane (AOM) and dextran sulfate sodium (DSS)-induced CAC. AB23A treatment alleviated the body weight loss, disease activity index, colon tumor load, tissue injury, and inflammatory cytokine changes in CAC mice. The gut microbiota of AB23A-treated mice was characterized with high microbial diversity, the reduced expansion of pathogenic bacteria, such as Klebsiella, Citrobacter, and Akkermansia, and the increased growth of bacteria including Bacteroides, Lactobacillus, and Alloprevotella. These data reveal that AB23A has the potential to represent novel prebiotics that may be used to treat CAC in the future