Brca1

ENCODES a protein that exhibits chromatin binding; damaged DNA binding (ortholog); enzyme binding (ortholog); INVOLVED IN positive regulation of protein import into nucleus; response to estradiol; response to genistein; PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; forkhead class A signaling pathway; homologous recombination pathway of double-strand break repair; ASSOCIATED WITH ductal carcinoma in situ; Experimental Mammary Neoplasms; adenoid cystic carcinoma (ortholog); FOUND IN mitochondrial matrix; BRCA1-A complex (ortholog); BRCA1-B complex (ortholog); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether

编码一种表现出染色质结合特性的蛋白质；受损DNA结合（同源）；酶结合（同源）；参与蛋白质进入细胞核的正向调控；对雌二醇的反应；对大豆苷的反应；参与着丝粒错位（ATM）信号通路；forkhead家族A类信号通路；双链断裂修复的同源重组途径；与导管原位癌相关；实验性乳腺肿瘤；腺样囊性癌（同源）；存在于线粒体基质中；BRCA1-A复合物（同源）；BRCA1-B复合物（同源）；与（+）-五味子素B、1-萘基异硫氰酸酯、2,2',4,4'-四溴二苯醚相互作用。