Treatment with Oxaliplatin and Irinotecan in colorectal metastatic tumors with high expression of thymidilate synthase (TS).

Primary objectives: The principle end-point of the study is to evaluate the therapeutic response achieved in patients with metastatic colorectal cancer with high espression of the enzyme thymidilate synthase (TS), treated with a combiation regimen not including fluoropirimidines.