Postnatal day 1.5 small intestine transcriptome analysis in wild type and ASE-/- mice

By comparing the small intestine transcriptomes of 4 wild type and 3 ASE-/- mice, we identified several oxidative balance related genes are expressed differentially between WT and ASE-/- in postnatal day 1.5 small intestine when dietary nutrient uptake became vital to support neonatal physiology. We here discover that the asymmetry enhancer of Pitx2 is critical for proper redox homeostasis.This is in agreement with the previous discovery that Pitx2 is important for cellular oxidative balance and is therefore important in cellular maturation and differentiation. Intestine mRNA profiles of 1.5-day old wild type (WT) and ASE-/- mice本研究通过对比4只野生型（wild type, WT）小鼠与3只ASE-/-小鼠的小肠转录组，在出生后1.5天的小肠组织中鉴定出多个与氧化平衡相关的基因在WT与ASE-/-小鼠间存在差异表达。该阶段膳食营养摄取已成为支撑新生小鼠生理功能的关键需求。本研究证实，Pitx2的不对称增强子对维持正常氧化还原稳态至关重要，这与既往研究结论相符：Pitx2对细胞氧化平衡具有重要调控作用，进而参与细胞成熟与分化过程。本数据集涵盖出生后1.5天的野生型（WT）与ASE-/-小鼠的小肠mRNA表达谱。