Synthesis of Mutual Azo Prodrugs of Anti-inflammatory Agents and Peptides Facilitated by α-Aminoisobutyric Acid
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https://figshare.com/articles/dataset/Synthesis_of_Mutual_Azo_Prodrugs_of_Anti_inflammatory_Agents_and_Peptides_Facilitated_by_Aminoisobutyric_Acid/2575894
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资源简介：
Reported is the synthesis of azo mutual prodrugs of the
nonsteroidal
anti-inflammatory agents (NSAIDs) 4-aminophenylacetic acid (4-APAA)
or 5-aminosalicylic acid (5-ASA) with peptides, including an antibiotic
peptide temporin analogue modified at the amino terminal by an α-aminoisobutyric
acid (Aib) residue. These prodrugs are designed for colonic delivery
of two agents to treat infection and inflammation by the bacterial
pathogen Clostridium difficile.
创建时间：
2016-02-22
