AI-Enhanced Nano-Spectroscopic Screening (AINSBS): A Perspective Towards a Paradigm Shift in Early Cancer Detection

This perspective paper introduces AI-Enhanced Nano-Spectroscopic Screening (AINSBS), a transformative conceptual framework for early cancer detection through a non-invasive, cost-effective, and scalable liquid biopsy platform. AINSBS synergistically integrates three advanced technologies: (1) aptamer-functionalized gold nanoparticles (AuNPs) for high-specificity capture of circulating tumor cells (CTCs), (2) surface-enhanced Raman spectroscopy (SERS) for ultra-sensitive, label-free molecular fingerprinting at the single-cell level, and (3) 1D convolutional neural networks (1D-CNNs