DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity

ChEBI2014-01-28 更新2026-07-21 收录

DNA损伤修复

基因组稳定性

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-46260 数据链接链接失效反馈

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DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity

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2014-01-28

Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair

DNA损伤修复

抗癌药物设计

Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a 3′–5′ DNA helicase that

NIAID Data Ecosystem40

Transcriptome analysis of IR-treated HL-60 cells (shCtrl and shPTIP)

DNA损伤修复

基因表达调控

To explore the underlying molecular mechanisms behind DNA damage repair, gene expression profiles of shCtrl- and shPTIP (#1 and #2)-transduced HL-60 cells at 0 min and 180 min after IR were examined b

NIAID Data Ecosystem10

BRCA2 prevents PARPi-mediated PARP1 retention to protect RAD51 filaments

DNA损伤修复

蛋白质功能分析

Manuscript number: 2023-10-18174A-Z This folder contains raw data for both FACS and smFRET analyses used in the manuscript. The smFRET dataset has been post-processed to remove trajectories affected

NIAID Data Ecosystem00

p38-MK2 regulate RNA metabolism after UV light-induced DNA damage

DNA损伤修复

转录调控

Ultraviolet (UV) light induces the formation of bulky UV photoproducts in the genome that interfere with DNA replication and transcription. It is well-established how human cells repair UV light-induc

NIAID Data Ecosystem20

3,N(4)-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase

DNA损伤修复

致突变加合物

Exocyclic DNA adducts are generated in cellular DNA by various industrial pollutants such as the carcinogen vinyl chloride and by endogenous products of lipid peroxidation. The etheno derivatives of p

PubMed Central1998-07-21 更新00

DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity

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