RAS GUANINE EXCHANGE FACTOR SOS1 (REM-CDC25) IN COMPLEX WITH KRAS(G12C) AND FRAGMENT SCREENING HIT F4
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https://pdbj.org/mine/summary/6epp
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RAS GUANINE EXCHANGE FACTOR SOS1 (REM-CDC25) IN COMPLEX WITH KRAS(G12C) AND FRAGMENT SCREENING HIT F4 Descriptor: GLYCEROL, GTPase KRas, Son of sevenless homolog 1, ... Authors: Hillig, R.C, Moosmayer, D, Hilpmann, A, Bader, B, Schroeder, J, Wortmann, L, Sautier, B, Kahmann, J, Wegener, D, Briem, H, Petersen, K, Badock, V. Deposit date: 2017-10-12 Release date: 2019-02-06 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
创建时间：
2017-10-12
