Promoter hypermethylation of TMEM130 is associated with tumor cell migration in cervical cancer

Cervical cancer is the fourth most common cancer and the second leading cause of cancer-related deaths in women worldwide. DNA methylation affects the prognosis of cervical cancer by changing gene expression. We performed an epigenome-wide association study to investigate whether the role of DNA methylation in TMEM130 gene expression is associated with the function of TMEM130 in cervical cancer cell migration.TMEM130 downregulation and hypermethylation might contribute to cervical cancer migration. These findings suggested that TMEM130 might be a promising biomarker for cervical cancer.