Selective IgM digestion improves anti-AAV IgG detection in the immune complex assay format
收藏NIAID Data Ecosystem2026-05-02 收录
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https://figshare.com/articles/dataset/Selective_IgM_digestion_improves_anti-AAV_IgG_detection_in_the_immune_complex_assay_format/30042099
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资源简介：
To confirm the observation of IgM interference in the anti–adeno-associated virus (AAV) IgG immune complex (IC) assay format and to verify that IgM-specific digestion can improve anti-AAV IgG detection in IC assays.
Treatment-emergent anti-AAV2 and anti-AAV9 IgG signals were measured in IC assays with and without IgM-specific digestion. Anti-AAV2 and anti-AAV9 IgM signals were measured in parallel.
IgM digestion increased anti-AAV2 and anti-AAV9 IgG signals when anti-AAV2 or anti-AAV9 IgM were present in the matrix.
Co-existing anti-AAV IgM cause interference in the anti-AAV IC assay format. Selective IgM digestion improves the detection of anti-AAV IgG in the IC assay.
创建时间：
2025-09-03
