Brain functional connectivity data in anesthetized participants and patients with neuropathological or psychiatric diagnoses

Five fMRI datasets were collected from independent research sites including: propofol deep sedation (PDS; drug effect site concentration= ~2.4 μg/ml) in Dataset-1, propofol general anesthesia (PGA; drug effect site concentration= 4.0 μg/ml) in Dataset-2, ketamine anesthesia (KA) in Dataset-3, unresponsive wakefulness syndrome (UWS) in Dataset-4, and schizophrenia (SCHZ), bipolar disorder (BD), and attentional deficit hyperactivity disorder (ADHD) in Dataset-5. Following fMRI data preprocessing, the fMRI time courses were extracted from 400 cortical areas according to a well-established brain parcellation scheme (Schaefer's 400 ROIs). A connectivity matrix was then calculated using Pearson correlation resulting in a 400x400 connectivity matrix for each participant and each condition.