Myelodysplastic syndromes and chronic myelomonocytic leukemia (CMML) are characterized by mutations in epigenetic modifiers and aberrant DNA methylation. DNA methyltransferase inhibitors (DMTis) are u

NIAID Data Ecosystem50

Specific methylation marks in promoter regions are associated to the pathogenic process of Chronic Chagas disease Cardiomyopathy by modifying transcription factor binding patterns [RNA-Seq]. Specific methylation marks in promoter regions are associated to the pathogenic process of Chronic Chagas disease Cardiomyopathy by modifying transcription factor binding patterns [RNA-Seq]

查加斯病病理机制

表观遗传生物标志物

Chagas disease, caused by Trypanosoma cruzi, is an endemic parasitical disease of Latin America, affecting 7 million people. Although most patients are asymptomatic, 30% develop complications, includi

NIAID Data Ecosystem30

DNA methylation profiles in pneumonia patients reflect changes in cell types and pneumonia severity

表观遗传生物标志物

肺炎临床预测

Immune cell-type composition changes with age, potentially weakening the response to infectious diseases. Profiling epigenetics marks of immune cells can help us understand the relationship with disea

NIAID Data Ecosystem70

Methylation studies in naked mole rat. Part 1

DNA甲基化衰老

表观遗传生物标志物

An Infinium microarray platform (GPL28271, HorvathMammalMethylChip40) was used to generate DNA methylation data from many tissues of the naked mole rat We generated DNA methylation data from n=289 ti

NIAID Data Ecosystem30

Blood methylomes of schizophrenia patients differing in their response to risperidone treatment

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