Transcriptomic comparisons of macroscopically normal-appearing and scarred lung tissues in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) produces scarring in the peripheral and basilar regions of the lung with macroscopically normal-appearing tissue in the central and apical areas. This study involved comparing transcriptomic profiles of the latter with transcriptomes of scarred IPF and healthy control lung tissues. The primary goal of the research was to elucidate the pathobiology of the disease in its earliest stages. Tissue samples were taken from lung explants of 3 IPF patients and healthy lung tissue from 3 transplant donors. Dataset includes 10 sequence reads from macroscopically normal-appearing areas and 8 from scarred regions from IPF lungs, and an additional 8 from the normal control tissue for a total of 26 samples. 1 supplementary PDF and 7 supplementary datasets in Excel are available at: http://dx.doi.org/10.1016/j.cellimm.2018.01.002

特发性肺纤维化（IPF）导致肺部周边和基底区域出现疤痕，而中央和尖部区域在宏观上呈现正常组织。本研究旨在比较中央和尖部区域的转录组学特征与疤痕型IPF以及健康对照肺组织的转录组。研究的主要目标在于阐明疾病早期阶段的病理生物学。研究样本来自3名IPF患者的肺移植标本以及3名移植供体的健康肺组织。数据集包括来自宏观正常区域10个序列读数和来自疤痕区域的8个序列读数，以及来自正常对照组织的8个序列读数，共计26个样本。此外，还包括1份补充PDF文件和7个补充Excel数据集，可通过以下链接获取：http://dx.doi.org/10.1016/j.cellimm.2018.01.002