RNA sequencing in primary human macrophages overexpressing ETS2
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.omicsdi.org/dataset/ega/EGAS00001007554
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We investigated an intergenic haplotype on chr21q22, linked to five different inflammatory diseases, and discovered a mechanism that orchestrates macrophage responses during chronic inflammation. We delineated how the risk haplotype increases expression of the causal gene, ETS2, and demonstrated that ETS2 is necessary for inflammatory macrophage effector functions. To establish whether ETS2 is sufficient to drive inflammatory responses, we overexpressed ETS2 in a dose-dependent manner and performed RNA-sequencing to characterise the transcriptional effects.EGA study EGAS00001007554
创建时间：
2024-10-30
