Adverse Outcome Pathway on Inhibition of the mitochondrial complex I of nigro‑striatal neurons leading to parkinsonian motor deficits
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This AOP describes the linkage between inhibition of complex I (CI) of the mitochondrial respiratory chain and motor deficit as in parkinsonian disorders. Binding of an inhibitor to CI has been defined as the molecular initiating event (MIE) that triggers mitochondrial dysfunction, impaired proteostasis, which then cause degeneration of...
