The impact of U2AF2 deficiency on gene expression in ovarian cancer cells

U2AF2 is an RNA processing-related factor that has a substantial impact on various cellular processes and is also closely associated with cancer development.Here, functional experiments demonstrated that U2AF2 significantly promotes ovarian cancer progression.RNA-seq analysis revealed that differentially expressed genes downstream of U2AF2 are significantly enriched in the Wnt signaling pathway, which was validated by Western blot.In summary, our data provide new molecular insights into ovarian cancer. Overall design: The U2AF2 SINC and U2AF2 SI OVCA433 ovarian cancer cell lines were used for 3v3 RNA-seq.