NETs promote invasive behavior of fibroblast-like synoviocytes through GPIba in rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and joint destruction. While neutrophil extracellular traps (NETs) have been implicated in RA pathogenesis, their effects on fibroblast-like synoviocytes (FLS) remain poorly understood. This study aims to investigate the role of NETs in RA FLS migration, proliferation, and invasion, as well as the underlying molecular mechanisms.