sncRNAs associated with Maternally inherited Diabetes and Deafness

Maternally inherited Diabetes and Deafness MIDD)is a rare form of adult-onset diabetes that can be difficult to diagnose due to its wide clinical phenotype. Transfer RNA-derived small fragments tsRNAs are a novel class of small noncoding RNAs sncRNAs that, similar to microRNAs, have significant potential as serum biomarkers due to their stability and ease of detection. We investigated the diagnostic potential of two sncRNAs ValCAC and miR-23b-3p identified from small-RNA sequencing studies of serum samples from healthy controls, Type 1 Diabetes, Type 2 Diabetes and MIDD subjects.