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Complex chromosome rearrangements from mitotic errors
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2020-04-08
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Chromothripsis drives DNA amplification in cancer cells developing drug resistance. Chromothripsis drives DNA amplification in cancer cells developing drug resistance
Gene amplification leading to increased oncogene expression or anticancer drug resistance is a frequent event in cancer. Cytogenetic, genomic, and transcriptomic analyses were used to determine the in
NIAID Data Ecosystem70
Additional file 3: Table S2. of Molecular dissection of germline chromothripsis in a developmental context using patient-derived iPS cells
Normalized RNA expression values for all 67 protein-coding genes located near the breakpoints. Expression levels of fragments of genes disrupted by the chromothripsis breakpoints are shown separately.
DataCite Commons2024-12-17 更新60
Chromothripsis in healthy individuals affects multiple protein-coding genes and can result in severe congenital abnormalities in offspring [case 3]
Chromothripsis represents an extreme class of complex chromosome rearrangements (CCRs) with major effects on chromosomal architecture. Although recent studies have associated chromothripsis with conge
NIAID Data Ecosystem50
Mitotic clustering of pulverized chromosomes from micronuclei
Complex genome rearrangements can be generated by the catastrophic pulverization of mis-segregated chromosomes trapped within micronuclei through a process known as chromothripsis. Since each chromoso
NIAID Data Ecosystem60
Additional file 3: Table S2. of Molecular dissection of germline chromothripsis in a developmental context using patient-derived iPS cells
Normalized RNA expression values for all 67 protein-coding genes located near the breakpoints. Expression levels of fragments of genes disrupted by the chromothripsis breakpoints are shown separately.
DataCite Commons2024-12-17 更新60
