Expression data from 2-week and 2-month-old mouse testes extracted from wild-type (WT), Sf1:Cre,Prkar1afl/fl (prKO), Amh:Cre,Prkar1afl/fl (srKO), Cyp11a1:Cre,Prkar1afl/fl (lrKO).

Prkar1a encodes the regulatory subunit R1a of the proteine kinase A. Prkar1a ablation in the testis results in profound alterations of tissue homeostasis leading to tumor development and infertility. We used microarrays to analyze gene expression in response to Prkar1a gene ablation in testicular somatic cells (derived from SF1+ cells) (prKO model), in Sertoli cells (sKO model) or in Leydig cells (lrKO model) in 2-week and 2-month-old mouse testes. Testes were dissected from prKO (3-4), srKO (4), lrKO (4) and wild-type littermate (8) mice at 2 weeks and 2 months.