Analysis of serum lipids in patients with polycystic ovary syndrome using UPLC/Q-TOF-MS

<b>Amis:</b> To determine the serum lipidomic profile of patients with ovarian syndrome using the UPLC-Q-TOF/MS technique and explore its pathogenesis, better diagnosis, and treatment. <b>Methods: </b>This was a prospective cross-sectional study conducted on 81 patients with ovarian syndrome and 20 healthy women, using UPLC–Q-TOF/MS for untargeted lipidomics. The differences in features between the two groups were identified using the principal component analysis (PCA), orthogonal partial least squares discriminant analysis (OPLS-DA), and hierarchical clustering analysis.<b>结果：</b>甘油脂、甘油磷脂和鞘磷脂的代谢不同。相比于对照组，水平 磷脂酰胆碱，磷脂酰，磷脂酰肌醇，的oxphosphatidylinositol和lysophosphatidylethanol均降低，而水平 的磷脂酰甘油，溶血磷脂酰肌醇，和三酰基甘油的增加。在另一方面，该水平 的鞘磷脂 增加或根据离子模式减少。 <b>结论</b><b>：</b>卵巢综合征患者与对照组在甘油磷脂生物合成途径的变化和作为第二信使的细胞信号转导方面存在显着差异。这样，在效果 基因调控，糖代谢，脂质代谢，和炎症反应都与的发生相关 的卵巢综合征及其并发症。 <br>