Conduction responses of autonomic [13,14] and cutaneous [11,12] C-fiber models and experiments.

For the four published models, the values in each cell are the responses for 1 μm fibers. For the “Target” columns, the values are the lower and upper bounds for that target response used in the optimization, as measured in the experiments of the “References” columns ±10% (autonomic) and ±0% (cutaneous). Each simulation was conducted at the indicated temperature. The bolded values represent model responses that are not within the experimental range. NA: not applicable.