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Activation of GPR3-b-Arrestin2-PKM2 by DPI enhanced glycolysis in kupffer cells [mouse KC]

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NIAID Data Ecosystem2026-05-01 收录
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To investigate the transcriptional changes of Kupffer cells isolated from HFD-induced obesity mice treated with DPI in vivo. Mice were fed with HFD for total 8 weeks. Mice were dosed with DPI (2mg/kg) every 5 days from week 3. At week 8, single cells were prepared from mouse livers. Kupffer cells were FAC-sorted by F4/80+CD11b+. RNA was isolated and purified by Qiagen Rneasy micro kit and applied to RNAseq

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2024-02-14
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