Asymmetric Total Synthesis of (−)-Vinigrol
收藏NIAID Data Ecosystem2026-03-11 收录
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资源简介：
A new strategy was developed for the asymmetric total synthesis of (−)-vinigrol. The strategy involved a linear sequence of 15 steps from 3-methyl-butanal (14 steps from chloro-dihydrocarvone) and did not need protecting groups. The synthetically challenging 1,5-butanodecahydronaphthalene core was constructed efficiently via a type II intramolecular [5+2] cycloaddition, followed by a unique ring-contraction cascade.
创建时间：
2019-09-23
