Oxidative stress-related biomarkers in oral squamous cell carcinoma patients: a systematic review and meta-analysis - Supplementary table 1

Aim: This meta-analysis was conducted to evaluate the serum and salivary levels of oxidative stress-related
biomarkers in oral squamous cell carcinoma (OSCC) patients compared with controls. Methods: A search
of relevant articles that were published between 1 January 2000 and 20 March 2022, was conducted on
three electronic databases (Embase, PubMed and Cochrane Library). Results: A total of 15 articles were
included in the meta-analysis. The levels ofmalondialdehyde (MDA), superoxide dismutase (SOD), reduced
glutathione (GSH), glutathione peroxidase (GPx) in serum and MDA and GSH in saliva were significantly
changed in the OSCC group compared with healthy controls. Conclusion: This study suggests that some
oxidative stress biomarkers may be potential biomarkers in early OSCC diagnosis.