Selective expression of chemokine receptors during T-cell polarization

Selective expression of chemokine receptors during T-cell polarization. Pathway based on Biocarta pathway (M4047). https://cgap.nci.nih.gov/Pathways/BioCarta/h_nktPathway The polarization of T cells into Th1 and Th2 cells is associated with their expression of subsets of chemokine receptors. While not being exposed to antigens, naïve T cells express CXCR4 and CCR7 receptors. TGF-beta van induce semi-naive T cells, that express a subset of CCR4 and CCR7 receptors. Th1 express CXCR3, CCR1, CCR2 and CCR5 receptors, while Th2 express CCR2, CCR3 and CCR5. However these subsets are not absolute as there is overlap between the expression of receptor subsets and thus between Th1 and Th2 cells.

在T细胞极化过程中选择性表达趋化因子受体。该路径基于Biocarta通路（M4047）。https://cgap.nci.nih.gov/Pathways/BioCarta/h_nktPathway T细胞向Th1和Th2细胞极化与其表达的趋化因子受体亚群相关。即便未接触抗原，原始T细胞亦表达CXCR4和CCR7受体。TGF-β可诱导半原始T细胞，表达CCR4和CCR7受体的亚群。Th1细胞表达CXCR3、CCR1、CCR2和CCR5受体，而Th2细胞表达CCR2、CCR3和CCR5。然而，这些亚群并非绝对，因为受体亚群的表达存在重叠，从而Th1和Th2细胞之间也存在表达的重叠。