Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover antibacterial agents. Herein, we design and synthesize a compound of TPA2PyBu that kills both Gram-nega
Based on ONC212, a previously reported activator of hClpP and SaClpP, a novel class of SaClpP-selective imipridones featuring a substituted group at C8 was designed, synthesized, and evaluated. Among
1H & 13C NMR spectra Figure S1. Modification of salicylidene and heteroarylidene derivatives Figure S2. Time-dependent interaction of 4d with VRSA at MIC and sub-MIC values Figure S3. Time-depe
Bacterial resistance to antibiotic therapy is a major world health problem, which has been exacerbated by a decline in antimicrobial drug development and the emergence of...
