Coexpression Gene Network Analysis reveals novel regulatory pathways involved in Porto-sinusoidal vascular disease pathophysiology

Porto-sinusoidal vascular disease (PSVD) is a rare vascular liver disease of unknown etiology that causes portal hypertension. It usually affects young individuals and shorts live expectancy. The deregulated pathways involved in PSVD development are unknown and therefore we lack curative treatments. The purpose of this study was to better understand the biological pathology of PSVD integrating transcriptomic and clinical data by comprehensive network-based modeling with the final aim of uncovering altered biological processes in patients with PSVD. Overall design: RNA-seq transcriptomic analysis using frozen livers from 8 PSVD, 8 liver cirrhosis (LC) and 8 Healthy subjects(HNL).