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Precision targeting of C3+ reactive astrocyte subpopulation with endogenous ADAR in iPSC-derived model

NIAID Data Ecosystem2026-05-02 收录

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iPSC疾病模型构建

数据链接：

https://www.ncbi.nlm.nih.gov/sra/ERP173616 数据链接链接失效反馈

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资源简介：

C3 sensor-equipped astrocytes activated by inflammatory cytokines

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创建时间：

2025-06-20

iPSC疾病模型构建

细胞功能基因组学

Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform that enables the systema

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Frataxin deficiency drives cardiac dysfunction and transcriptional dysregulation in Friedreich ataxia iPSC model

遗传性心肌病机制研究

iPSC疾病模型构建

Friedreich ataxia (FRDA) is a progressive neuromuscular degenerative disorder caused by GAA repeat expansions in the FXN gene, leading to frataxin deficiency and multisystem pathology. Cardiomyopathy

NIAID Data Ecosystem10

X-omics iPSC data analysis workflow data and metadata files

罕见神经发育障碍多组学分析

iPSC疾病模型构建

Multi-omics analysis for rare neurodevelopmental disorders. The material consists of patient-derived IPSCs from NANS, CDH2, and DM1 patients. In some cases the genotype was rescued using CRISPR/Cas9 g

Zenodo2026-03-20 更新30

CD51 expression delineates functionally distinct astrocyte subpopulations in neural circuits

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神经回路可塑性

Astrocytes execute a diverse range of tasks that facilitate brain physiology, raising the possibility that these diverse astrocytic roles are enabled by functionally distinct subtypes1,2. Recent studi

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Precision targeting of C3+ reactive astrocyte subpopulation with endogenous ADAR in iPSC-derived model

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