Interstitial Cystitis cohort study

The Interstitial Cystitis Data Base (ICDB) cohort study was a prospective, multicenter clinical study of patients with Interstitial Cystitis (IC). The study gathered data to investigate the treated history of IC and identify patient subgroups with specific symptoms, physical findings, histopathologic findings from bladder biopsies, and treatment responses. Data was collected on patients at baseline and longitudinally concerning demographic and diagnostic information, medical history, dietary intake, urinary symptoms, and treatments and their outcomes. Additionally, bladder tissue specimens were stored in a specimen bank. Initial analyses on patient data supported the clinical observation that IC is a chronic symptom complex and showed that no current treatments had a significant impact on symptoms over time.间质性膀胱炎数据库（Interstitial Cystitis Data Base，简称ICDB）队列研究是一项针对间质性膀胱炎（Interstitial Cystitis，简称IC）患者的前瞻性多中心临床研究。本研究通过收集数据以探究间质性膀胱炎的诊疗历程，并识别存在特定症状、体格检查结果、膀胱活检组织病理表现及治疗反应的患者亚群。研究在基线阶段及纵向随访过程中，采集了患者的人口统计学信息、诊断资料、病史、饮食摄入情况、尿路症状、治疗方案及其转归数据。此外，膀胱组织标本已存入标本库。针对患者数据的初步分析印证了“间质性膀胱炎是一种慢性症状复合体”这一临床观察结论，同时证实当前尚无任何疗法可长期显著改善患者症状。