Gene expression data for liver, adipose, and skeletal muscle tissues of MKR and Healthy mice

MKR mice is a Type 2 Diabetic mice, which was created by expressing mutation in IGF1 receptor in the skeletal muscle, and is widely used in diabetes research. Gene expression differences between MKR mice and Healthy (Wild type) mice are poorly understood. We used microarrays to detail the differences between gene expression in liver, fat, and skeletal muscle of MKR and Healthy mice. Male 10-weeks old FVB/N - MKR and wild type mice were used for the microarray studies. 3 biological replicates for each tissue type and for both MKR and WT mice were used in the studies.MKR小鼠属于2型糖尿病小鼠模型，其构建方式为在骨骼肌中表达突变型胰岛素样生长因子1受体（IGF1 receptor），目前已被广泛应用于糖尿病研究领域。目前学界对MKR小鼠与健康野生型（Wild type，WT）小鼠之间的基因表达差异仍知之甚少。本研究采用微阵列（microarrays）技术，系统解析了MKR小鼠与健康野生型小鼠在肝脏、脂肪组织及骨骼肌中的基因表达差异。本微阵列实验选用10周龄雄性FVB/N背景的MKR小鼠与野生型小鼠作为实验对象，各组织类型、MKR组与野生型（WT）组均设置3次生物学重复（biological replicates）。