Identification of gene signature in microdissected omental adipose tissue from high grade serous ovarian cancer patients. Identification of gene signature in microdissected omental adipose tissue from high grade serous ovarian cancer patients

Advanced ovarian cancer usually spreads to the omentum. However, the omental cell-derived molecular determinants modulating its progression have not been thoroughly characterized. Transcriptome profiling was performed on microdissected omental adipose tissue obtained from patients with benign gynecologic diseases and on cancer-associated omental tissue obtained from patients with advanced-stage, high grade serous ovarian cancer. Overall design: Microarray analysis was performed on four microdissected omental adipose tissue from patients with benign gynecologic diseases and ten cancer-associated omental tissue obtained from patient with high grade serous ovarian cancer