Data set from "<b>HIV status modifies the association between gender identity and depression among sexual and gender minorities in Abuja, Nigeria</b>"

Dataset used in the paper, "<b>HIV status modifies the association between gender identity and depression among sexual and gender minorities in Abuja, Nigeria</b>," described in the abstract below.<b>Background</b>: In Nigeria, sexual and gender minorities (SGM) experience disproportionately high rates of depression, exacerbated by layered stigma related to gender identity and HIV status. However, little is known about how HIV status may modify the relationship between gender identity and depression in this context.<b>Methods</b>: We conducted a cross-sectional analysis using baseline data from 977 SGM participants recruited through respondent-driven sampling at an SGM-friendly clinic in Abuja, Nigeria (2023–2024). Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9), with scores ≥10 indicating major depression symptomatology. We employed multivariable logistic regression to examine associations among gender identity, HIV status, and depression, including interaction effects.<b>Results</b>: Overall, 18% of participants exhibited major depression symptomatology. Depressive symptoms were more common among transgender women (25%) and non-binary individuals (26%) than cisgender men (16%), and higher among persons living with HIV (PLHIV; 20%) compared to those without (15%). In adjusted models, both transgender women (aOR 2.05; 95% CI: 1.09–3.88) and non-binary individuals (aOR 2.38; 95% CI: 1.43–3.95) had significantly higher odds of depression than cisgender men. Financial insecurity (aOR 5.82; 95% CI: 3.82–8.89) and employment (aOR 1.68; 95% CI: 1.15–2.45) were also independently associated with depression. Notably, the joint effect of non-cisgender identity and HIV was supra-additive: PLHIV who were non-binary had an aOR of 4.10 (95% CI: 2.16–7.77) for depression, with a relative excess risk due to interaction (RERI) of 2.96.<b>Conclusions</b>: HIV status modifies the association between gender identity and depression among SGM in Nigeria. These findings underscore the need for intersectional, stigma-informed mental health interventions and affirming care models that address the unique vulnerabilities faced by PLHIV with non-cisgender identities.本数据集来自论文《尼日利亚阿布贾性与性别少数群体中HIV状态对性别认同与抑郁关联的调节作用》，其摘要如下。 <b>背景</b>：在尼日利亚，性与性别少数群体（sexual and gender minorities, SGM）承受着不成比例的高抑郁发病率，与性别认同和HIV感染状态相关的多层污名进一步加剧了这一状况。然而目前针对该背景下HIV状态如何调节性别认同与抑郁之间的关联仍知之甚少。 <b>方法</b>：本研究采用横断面分析方法，使用2023—2024年在尼日利亚阿布贾一家支持性与性别少数群体的诊所中，通过应答者驱动抽样招募的977名SGM参与者的基线数据。抑郁症状采用患者健康问卷9项量表（Patient Health Questionnaire-9, PHQ-9）进行评估，得分≥10分提示存在重度抑郁症状。我们采用多变量logistic回归分析检验性别认同、HIV感染状态与抑郁之间的关联，并纳入交互效应分析。 <b>结果</b>：总体而言，18%的参与者表现出重度抑郁症状。跨性别女性（25%）与非二元性别群体（26%）的抑郁症状检出率高于顺性别男性（16%）；HIV感染者（persons living with HIV, PLHIV）的检出率（20%）亦高于未感染者（15%）。经校正的模型结果显示，相较于顺性别男性，跨性别女性（校正优势比aOR 2.05；95%置信区间CI: 1.09–3.88）与非二元性别群体（aOR 2.38；95% CI: 1.43–3.95）的抑郁发生风险显著升高。经济不稳定（aOR 5.82；95% CI: 3.82–8.89）与就业状态（aOR 1.68；95% CI: 1.15–2.45）亦与抑郁存在独立关联。值得注意的是，非顺性别身份与HIV感染的联合效应呈现超相加性：非二元性别HIV感染者的抑郁aOR为4.10（95% CI: 2.16–7.77），其交互导致的相对超额风险（relative excess risk due to interaction, RERI）为2.96。 <b>结论</b>：HIV状态可调节尼日利亚SGM群体中性别认同与抑郁之间的关联。本研究结果凸显了开展交叉性、基于污名认知的心理健康干预，以及能够应对非顺性别身份HIV感染者所面临独特脆弱性的肯定性照护模式的必要性。