The guide for selection of the BCV usecase.
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The table explains empirical rules that could be used for choosing appropriate BCV usecese depending on the expected diversity of DNA variants in a sample study. Expected diversity (eDiv) is the mean divergence of DNA variants expected in the sample. Prevailed mutation type is the most frequent type of mutations expected for sequenced DNA locus. Expected vocabulary distance (evDist) is maximal identity for DNA variants in the mixture with the sequences in the vocabulary that we expect: e.g. for human genome we can expect evDist = 0.001, for HBV surface antigen evDist<0.03. The vocabulary is considered as approximate if evDist≈eDiv; we cannot deconvolute mixture of DNA variants but still can detect indels if components of the mixture are similar. The vocabulary is considered as representative if evDist
创建时间:
2013-01-28



