Sulfolobus islandicus LC-MSMS - aKMT catalyzes extensive protein lysine methylation in the hyperthermophilic archaeon Sulfolobus islandicus but is dispensable for the growth of the organism

Analysis of the methylation of total cellular protein by mass spectrometry revealed that methylated proteins accounted for ~2/3 (1,158/1,750) and ~1/3 (591/1,766) of the identified proteins in the wild type and the mutant strains, respectively, indicating that there is extensive protein methylation in S. islandicus and that aKMT is a major protein methyltransferase in this organism.